Marijuana: With 52.5 million users in 2021, it offers relaxation but can lead to long-term mental health issues. – 

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Prescription pain relievers: 8.7 million misuse them in 2021, including opioids like oxycodone and hydrocodone. They relieve pain but can cause addiction and overdose. – – 

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Hallucinogens: 7.4 million people used them in 2021, including LSD and psilocybin. They alter perception but can lead to hallucinations and paranoia. – – – 

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Prescription tranquilizers or sedatives: 4.9 million misused them in 2021, including benzodiazepines like alprazolam. They reduce anxiety but can cause dependence and memory impairment. – – – – 

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Cocaine: 4.8 million people used it in 2021, offering an intense energy boost but posing serious health risks. – – – – – 

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Prescription stimulants: 3.7 million misused them in 2021, including Adderall. They enhance performance but can lead to addiction and psychosis. – 

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Methamphetamine: 2.5 million users in 2021, providing euphoria but causing severe damage to the body. – – 

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Inhalants: 2.2 million used them in 2021, often household products. They offer a brief high but can result in brain damage and organ failure.

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